Metizolam
A proper standard of dosing has not been established yet for this substance since it has not been studied formally and has a minimal history of human usage. However, it is highly recommended to practice caution while administering this substance due to its high potential for abusive use and potential side effects.
Etizolam (also known as Desmethyletizolam), is a psychoactive drug and a synthetic depressant of the thieno diazepine chemical class. It reportedly produces effects that are similar to those of Etizolam, including anxiety suppression, disinhibition, sedation, muscle rest, and memory suppression. It has a 60% longer half-life and is 50% less potent than Etizolam.
In 1995, a Japanese company patented Metizolam as a medication for treating anxiety. Apart from that, there is no known history of human usage until September 2015 when it was released as a grey area research chemical by online vendors.
Etizolam is an analog of benzodiazepine family and is commonly marketed under the names Depas, Etizolam, and Etilaam. Although not much is known about this research chemical, various researches suggest that it possesses hypnotic, skeletal muscle relaxant, sedative, anxiolytic, and anticonvulsant properties.
How Does Metizolam Work?
Etizolam is readily available for purchase from the internet in the form of tablets, solutions, and powder. It has excellent potential for abusive use over prescribed benzodiazepines since it can be easily purchased from the internet at lower prices. As of now, scientific literature lacks essential details about Metizolam such as its detailed analysis, and its distribution and metabolism in the body. Although pharmaceutical companies have developed this compound, it does not have any legal status as of now, except in the UK, Sweden, and Canada, where the production/supply of this substance is prohibited.
A Japanese corporation first marketed Etizolam as an anti-anxiety medicinal drug, but little is known about this research chemical. However, a few clinical reviews advocate that Metizolam can act as depressant, sedative, and muscle relaxant.
Metizolam consists of a Thiophene ring fused to a Diazepine ring. Although it structurally differs from its discern compound etizolam as its Triazole ring does no longer comprise methyl institution, however, each has the same fundamental shape, which means Metizolam has the same electricity of affecting cognitive performance in addition to assisting insomnia patients. To decide the exact answer, scientists and researchers must experiment on Metizolam for its role in sleep deprivation prevention. Research labs should buy high prison powders online at studies chemical dealer internet sites to get their excessive first-class studies chemical substances – Metizolam and Etizolam. This may help them to understand the effect of both compounds on people living with insomnia as well as determine the efficacy.
Why You Should Take: Metizolam The Benefits
Much is unknown about Metizolam due to the lack of proper scientific researches on this substance. All that is known about this substance comes from the minimal studies carried out and from the data collected from volunteers of different medicinal and research communities who used the importance.
A study was conducted to determine accurate means for detecting Metizolam in urine, as well as preliminary data on its metabolism. A 2mg tablet was ordered via the internet and was orally administered to a 54-year-old man. Urine samples were collected over six days in polypropylene tubes. After liquid extraction at 9.5pH, ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) was utilized to analyze Metizolam in the urine. Metizolam becomes detectable in hydrolyzed urine during the 46-h length, with concentrations continually decrease than 11 ng/mL. Approximately 0.3% of the initial dose was excreted in urines as total unchanged Metizolam throughout the first 24 h. The most relevant capability CYP- and UGT-established metabolites of Metizolam had been investigated in vitro the usage of human liver microsome incubation and, ultimately, liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF-MS) analysis.
Potential Side Effects of Metizolam
The harm potential due to long-term usage and toxicity dosage levels of Metizolam are not yet clear since the substance has not been adequately studied and analyzed in a scientific context. This is simply because of the lack of a known history of human usage. However, volunteer members of various research and medicinal communities who administered the substance on its own in low doses have reported no adverse effects; though, nothing can be said for sure.
Dosage is the main factor in determining the effects of Metizolam. If administered in large quantities, Metizolam can yield the following physical and cognitive results.
Where to Buy Online: Products Containing Metizolam
Conclusion
Metizolam is closely related to Etizolam and has similar effects; however, it is half as potent as Etizolam and possesses a 60% longer half-life. Although Metizolam has certain potential benefits such as anxiety suppression and muscle rest, it should be administered with caution and in small doses because of its harm and abuse potential. Etizolam can tend to be life-threatening if administered with other depressants, including alcohol and opiates.
References:
- Smokeys. “Metizolam for the Treatment of Insomnia like Etizolam.” High-Quality Research Chemicals Delivered Worldwide To Your Door, 31 Aug. 2017, www.smokeyschemsite.com/index.php?route=blog%2Farticle&article_id=66.
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- Haefely, W. “Benzodiazepine interactions with GABA receptors.” Neuroscience letters., U.S. National Library of Medicine, 29 June 1984, www.ncbi.nlm.nih.gov/pubmed/6147796.
- Weber, Karl‐Heinz, et al. “Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine.” European Journal of Organic Chemistry, WILEY‐VCH Verlag, 25 Jan. 2006, onlinelibrary.wiley.com/doi/10.1002/jlac.197819780806/abstract.