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Advantra Z is a stimulant derived from the bitter orange plant. It has synephrine as its primary active compound found in the fruit of the citrus aurantium plant. Synephrine is also known as bitter orange. Bitter orange is a plant that can be taken by mouth and applied to the skin. The peel, flower, leaf, fruit and juice are used to make supplements and medicines, while the peel is used to make oil for topical use. Synephrine is chemically very similar to the ephedrine and pseudo-ephedrine found in many OTC cold/allergy medications and in a number of weight loss and energy supplements.