Ursolic Acid
The estimated human dose is 1.6-6.4 mg/kg body weight for a 150 lb adult. Yet the standard dosage is 150 mg totaling 450 mg each day. Thrice of daily dosing is recommended with proper meals in between.
Ursolic acid is known as a pentacyclic triterpenoid or can sometimes is related to urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oic-acid. In the year 1920, it was discovered in the epicuticular waxes of apples and is widely present in peels of fruit, including herbs and spices like rosemary and thyme. Ursolic acid can also be found in bilberries, peppermint, oregano, lavender, cranberries, prunes, and elderflower. This can also be found in the Ayuverda herb commonly called the Holy Basil. Ursolic acid appears as a bodying agent that enables muscle mass increase and reduces fat mass.
As a naturally occurring triterpenoid, it decreases the invasion of human breast cancer cells by modulating c-Jun N-terminal kinase and mammalian target of rapamycin signaling. It has several anticancer activities. Ursolic acid can serve as a starting material for the synthesis of more potent bioactive derivatives, such as experimental antitumor agents.
How Does Ursolic Acid Work?
A naturally occurring substance found in apple peels, ursolic acid has been produced to muscle mass increase and support the loss of body fat. It also blocks molecular pathways that may cause muscle loss and weakness. Ursolic acid provides natural support for fat loss and, at the same time, sparing lean muscle tissue, which makes it an excellent supplement for dieters.
UA grips strength and exercise capacity, which also increased skeletal muscle mass. It provides a high level of endurance, lowers expressional genes in the development, and decreased indicators of accumulated fatigue and exercise-induced stress. Ursolic acid can also serve as a starting material for the synthesis of more potent bioactive derivatives such as antitumor agents.
Why You Should Take: Ursolic Acid The Benefits
In the dietary study, mice have been using to test the hypothesis. With this, mice have been depriving of eating or have undergone some surgical muscle denervation and discovered that ursolic acid lowers muscle atrophy.
An obese mouse then experimented, eight-week-old male mice given a high-fat diet with 0.14% ursolic acid for almost six weeks. After weeks of observation, studies discovered that ursolic acid increase Akt phosphorylation more than two-fold.
Potential Side Effects of Ursolic Acid
Ursolic acid has been known as an anti-fertility agent and lowers reproductive capability in the short run, which also lowers sperm motility. If side effects occur like impacts of brain function or any negative reaction from the supplements might as well best to see medical supervision.
Where to Buy Online: Products Containing Ursolic Acid
Conclusion
Ursolic acid is not popular because of its anticancer benefits. It is known for its power to increase muscle mass and brown fat while lowering the white fat in the human body. Low dosage is beneficial to skeletal muscles; higher dosages preserve muscle mass during fasting. Many of the effects reported are related to the insulin-signaling pathway of muscle anabolism in line with this proper dosage must be observed accordingly.
References:
http://www.phytochemicals.info/phytochemicals/ursolic-acid.php
https://www.ncbi.nlm.nih.gov/pubmed/20352621
https://brainwiz.org/research-reports/ursolic-acid-side-effects-holy-basil/