GLYCOPHASE

Many GDAs claim to assist insulin and promote glucose transport into muscle cells, but few do this. Most block carbohydrate absorption in the intestine but do nothing to help support the body in utilizing insulin to create the environment necessary for increased uptake into muscle cells.

Glycophase, a cutting-edge nutrient partitioning matrix, manages your blood glucose levels and prevents excess glucose from becoming body fat. This excess glucose is then stored in your muscles, giving you a more muscular body.

Here’s the list of the critical ingredients of GlycoPhase:

• Agmatine Sulfate
• Berberine HCl
• Bitter Melon
• Banaba Leaf
• Gymnema Sylvestre
• Alpha Lipoic Acid
• Na-R-ALA
• Saffron
• Chromium

Ingredient Breakdown

Agmatine Sulfate: Agmatine sulfate is one ingredient that has been proven to increase GLUT-4 transport and mRNA expression in skeletal muscles. This is achieved by indirect action on beta-endorphin, which promotes GLUT-4 translocation in skeletal muscle via activating imidazoline I2A. This makes it a key ingredient to ensure that glucose transport to the muscle cells is preferred over the fat cell.

Berberine HCl: Berberine HCI has been widely regarded as one of the most potent ingredients for supporting blood sugar reduction. Although Berberine’s exact mechanism of action is still being investigated, it is believed that its ability to activate AMPK is a driver of the regulation of carbohydrates. This is because of AMPK’s ability to promote insulin sensitivity and glucose uptake in a method independent of insulin itself; Berberine may promote glucose uptake in cells that have become insulin resistant, thereby effectively clearing the blood of glucose in even the most difficult of environments. 

Bitter Melon: Bitter Melon contains several active ingredients that stimulate glucose clearance in the blood. These include vicine and charantin. Each one of these exerts its hypoglycemic effect via different physiological modes of action, ranging from stimulation of skeletal muscle utilization to preservation islet B cells (cells integral to proper insulin functioning), thus governing most of the process that underpins blood glucose clearing and helps preserve the integrity of the process. Protecting Islet B cell health is essential, whereby the destruction of these cells results in a lack of insulin production. The destruction of these cells can lead to a decrease in insulin production. Bitter Melon prevents this downregulation of cytokines that cause islet cell death. These cytokines are interleukin-6, and tumor necrosis factors a. Although it is unlikely, the protection against this may be worth it as the consequences can be detrimental to your overall health and long-term longevity.

Banaba Leaf: Banaba leaf, most notably its primary active ingredient, Corsolic Acid, has been reported to decrease blood sugar levels within 60 minutes in human subjects through its ability to increase cellular uptake of glucose. In various other human trials, Banaba extracted for Corsolic Acid has decreased blood glucose by up to 30% in hours, even compared to placebo. A study that examined the effects of Banaba, Bitter Melon, and Gymnema on weight loss showed that subjects lost an average of 6 kilograms in 12 weeks. Banaba extract for Corsolic Acid was found to reduce blood glucose levels by as much as 30% in human trials. This is even more than the placebo. Its potential mechanism of action is its ability to stimulate Glut-4 Translocation and induce insulin receptor phosphorylation. Both of these actions promote glucose clearance.

Gymnema Sylvestre: Gymnemic acids have been proven to be a valuable tool in fighting obesity. The proposed method of action is through its ability to delay glucose absorption in the blood, thus blocking the over secretion of insulin which may, under normal circumstances, dump glucose into adipose tissue. Gymnemic Acids share a similar structure to glucose, which allows them to compete for the same receptor sites in the intestine, delaying the glucose’s absorption into the blood. Gymnema could also help curb sugar cravings because it can fill the tongue’s taste receptors and prevent the sugar molecules from stimulating the same receptors. Gymnema may also be effective in increasing insulin secretion, encouraging the regeneration of islet cells, and increasing glucose utilization.

Alpha Lipoic Acid: Alpha Lipoic Acid is a mitochondrial compound that plays a significant role in energy metabolism. It involves various biological processes, including neuroprotection and dopaminergic transmission, cholesterol transport, and energy expenditure. Alpha Lipoic Acid can significantly mediate the expression of crucial rate-limiting enzymes involved in glucose metabolism in murine models. This is capable of increasing the liver’s ability to produce glycogen. Its benefits in glucose uptake and AMPK activation are similar to Berberine.

Na-R-ALA: Na-R-ALA, the sodium version R isomer of Alpha Lipoic Acid, is the most stable and available ALA form. It functions similarly to Alpha Lipoic Acid but on a larger scale. Na-R-ALA is most commonly known for producing dramatic muscle pumps resulting from increased glucose uptake in skeletal muscle.

Saffron: Saffron is one of the most underrated glucose disposal agents currently available. It works via multiple methods to directly influence glucose uptake and insulin sensitivity in muscle cells, promoting muscle pumps and improving blood glucose clearance. It strongly increases cell insulin sensitivity through insulin-dependent and non-insulin-dependent pathways and significantly fosters Glut-4 transport through AMPK activation. Two distinct ways regulate glucose transport into the skeletal muscle. One is AMPK; the other is PI-3 Kinase. The pathways of P 3-Kinase include activation of Akt, which promotes glycogen synthesis, and activation of key enzymes responsible for Glut-4 transfer. AMPK, on the other hand, plays a crucial role in glucose and lipid metabolism. Both pathways increase phosphorylation and mitogen-activated kinase (MAPK) activation, which fully activates insulin-stimulated glucose metabolism via GLUT-4. Saffron starts both paths. This is why it effectively clears blood glucose into the skeletal muscle. It can also facilitate its preference for glycogen storage over adipose tissue storage.

Chromium: Chromium, an essential mineral that regulates insulin and blood glucose in the body, is deficient in approximately 25-50% of the US populace. Due to its vital role in blood sugar regulation, a lack of Chromium can cause glucose intolerance, fatigue, and anxiety. Supplementation with Chromium may help to reduce snacking and binging behavior.

Other ingredients: Vegetable Cellulose (capsule), Magnesium Stearate, Dicalcium Phosphate, Titanium Dioxide

Directions:

1. Take one capsule up to twice daily, fifteen minutes before meals, as a dietary supplement.
2. If using two capsules daily, space the doses evenly throughout the day, 15 minutes before meals containing at least 25 to 50 grams of carbohydrates.
3. Use one of the dosages 15 minutes before a pre-workout meal on workout days.

This product is not intended to diagnose or treat any medical condition. This product is for healthy adults over 18 years of age. Consult a Physician before using this or any dietary supplement. This product should not be used by women that are pregnant or nursing. Do not use it if you have any pre-existing medical condition or are taking the medication without consulting your Physician. Do not use without carbohydrates, as low blood sugar and nausea and dizziness may occur.